EOLP-01. PALLIATIVE CARE REFERRAL ACROSS THE DISEASE TRAJECTORY IN HIGH-GRADE GLIOMA

Abstract BACKGROUND Patients with high-grade glioma (HGG), WHO grade 3 or 4, have substantial palliative care needs. As evidence suggests early consultation (PCC) yields improved quality of life in advanced cancer, our aim was to determine the occurrence, timing, and factors associated PCC HGG. METHODS Adults HGG diagnosed between 8/3/2011 1/23/2020 were identified retrospectively from a large, academic, multi-center health system cancer registry. stratified by any prior (yes/no), timing disease phase: (1) diagnosis (before radiation), (2) initial treatment (first-line chemotherapy/radiation), (3) second-line (second-line last chemotherapy), (4) end-of-life (after chemotherapy). Univariate analyses (e.g., Chi-square test) conducted compare non-PCC groups, based on data distribution. RESULTS Of 621 patients, 134 (21.58%) received PCC, 14 (10.45%) referred during phase 1; 35 (26.12%) 2; 20 (14.93%) 3; 65 (48.51%) 4 median 74 days (IQR 15, 277) death. The majority referrals inpatient (111 (82.84%)). group did not differ significantly age, sex, language, race, ethnicity, but marital status: single (263 (42.35%) vs 187 (38.4%)), divorced/separated (37 (27.61%) 107 (21.97%)), married/civil union (17 (12.69%) 154 (31.62%)); (Chi-square p < .01). Compared non-PCC, more patients had glioblastoma histopathology (89.55% vs. 82.14%, = .04). CONCLUSION A minority ever which primarily occurred setting, half those for it phase. Thus, only about one 10 entire cohort potentially benefits PCC. Further studies should elucidate barriers facilitators